Folate-responsive neuropathy: report of 10 cases.
نویسندگان
چکیده
Ten patients with severe neurological disease that was clinically indistinguishable from subacute combined degeneration of the spinal cord were found to have normal serum vitamin B12 levels. All were folate deficient. Specific folate treatment led to significant reversal of the neuropathy. These findings indicate the need to review orthodox concepts of the role of folic acid in maintaining the integrity of the nervous system.
منابع مشابه
Folic acid-responsive neurological diseases in Japan.
Folic acid (folate) levels were measured in the serum of patients with various neurological diseases in Japan. Thirty-six patients showed decreased serum folate levels among 343 consecutive neurological patients (10.5%). Folate administration (15 mg/d) to folate-deficient patients improved neurological symptoms in 24 of 36 cases (67%). Serum folate levels were significantly lower in female than...
متن کاملDetection of folate deficiency in alcoholism using the peripheral blood lymphocyte deoxyuridine suppression test.
Twenty-seven alcoholic patients were studied for folate status. Twenty-two (81%) had neutrophil hypersegmentation and were detected as folate deficient by also having low serum folate, erythrocyte folate, lymphocyte folate and/or an abnormal peripheral blood lymphocyte deoxyuridine suppression test. Seventeen (63%) had an abnormal lymphocyte deoxyuridine suppression test and all 17 were correct...
متن کاملHereditary sensory and autonomic neuropathy: A case report
A 24-year old female patient with the history of pressure ulcers in distal extremities resulted in severe deformity will be reported. Her disease started when she was 9 years old and a similar history was found in her brother. In physical examination, pain and temperature sensations were impaired in distal extremities. Nerve conduction velocity showed impaired sensory and normal motor responses...
متن کاملMental Neuropathy as Initial Manifestation of Metastatic Breast Cancer: A Case Report and Review of the Literature
Introduction: Mental neuropathy is a sensory neuropathy characterized by hypoesthe-sia or paresthesia of the chin and lower lip. It can be a symptom of a latent malignant disease. Case Presentation: This report presents a case of a 34-year-old woman with a history of breast cancer who complained of severe pain and numbness of the right lower lip. We reviewed numerous reliable articles (throu...
متن کاملTopiramate-induced Neuropathy Mimicking Carpal Tunnel Syndrome: A Case Report
Carpel tunnel syndrome (CTS) is a condition in which median nerve compression results in paresthesias and pain in thewrist and hand. We are going to report a rare case of topiramate-induced neuropathy which clinically resembles CTS.Discontinuation of topiramate resulted in spontaneous resolution of numbness, paresthesia and pain in a few days. Highclinical suspicion is advised in patients who a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- British medical journal
دوره 1 6019 شماره
صفحات -
تاریخ انتشار 1976